Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Bing Li; Robert Peter Gale; Zefeng Xu; Tiejun Qin; Zhen Song; Peihong Zhang; Jie Bai; Lei Zhang; Yue Zhang; Jinqin Liu; Gang Huang; Zhijian Xiao

doi:10.1186/s13045-017-0472-5

Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Bing Li, Robert Peter Gale, Zefeng Xu, Tiejun Qin, Zhen Song, Peihong Zhang, Jie Bai, Lei Zhang, Yue Zhang, Jinqin Liu, Gang Huang, Zhijian Xiao

Producción científica: Letter › revisión exhaustiva

10 Citas (Scopus)

Resumen

We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.

Idioma original	English (US)
Número de artículo	99
Publicación	Journal of Hematology and Oncology
Volumen	10
N.º	1
DOI	https://doi.org/10.1186/s13045-017-0472-5
Estado	Published - may 2 2017
Publicado de forma externa	Sí

ASJC Scopus subject areas

Molecular Biology
Hematology
Oncology
Cancer Research

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10.1186/s13045-017-0472-5

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title = "Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis",

abstract = "We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.",

keywords = "Myeloproliferative neoplasm-associated myelofibrosis, Non-driver mutation, Targeted gene sequencing",

author = "Bing Li and Gale, {Robert Peter} and Zefeng Xu and Tiejun Qin and Zhen Song and Peihong Zhang and Jie Bai and Lei Zhang and Yue Zhang and Jinqin Liu and Gang Huang and Zhijian Xiao",

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doi = "10.1186/s13045-017-0472-5",

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T1 - Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

AU - Li, Bing

AU - Gale, Robert Peter

AU - Xu, Zefeng

AU - Qin, Tiejun

AU - Song, Zhen

AU - Zhang, Peihong

AU - Bai, Jie

AU - Zhang, Lei

AU - Zhang, Yue

AU - Liu, Jinqin

AU - Huang, Gang

AU - Xiao, Zhijian

PY - 2017/5/2

Y1 - 2017/5/2

N2 - We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.

AB - We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.

KW - Myeloproliferative neoplasm-associated myelofibrosis

KW - Non-driver mutation

KW - Targeted gene sequencing

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U2 - 10.1186/s13045-017-0472-5

DO - 10.1186/s13045-017-0472-5

M3 - Letter

C2 - 28464892

AN - SCOPUS:85018249626

SN - 1756-8722

VL - 10

JO - Journal of Hematology and Oncology

JF - Journal of Hematology and Oncology

IS - 1

M1 - 99

ER -

Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

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