Neutrophil mediated tumor cell cytotoxicity: role of the peroxidase system

R. A. Clark, S. J. Klebanoff

Producción científica: Articlerevisión exhaustiva

222 Citas (Scopus)

Resumen

A cytotoxic effect of human neutrophils on mammalian tumor cells is demonstrated. Cytotoxicity depends on the presence of intact neutrophils, phagocytosable particles, and a halide cofactor and is inhibited by azide, cyanide, and catalase. Neutrophils from patients with myeloperoxidase (MPO) deficiency or defective H2O2 production are not cytotoxic, but activity is restored by addition of purified MPO or H2O2 respectively. The findings support a mechanism involving the phagocytosis induced extracellular release of MPO and H2O2 and their reaction with a halide cofactor to damage the target cells.

Idioma originalEnglish (US)
Páginas (desde-hasta)1442-1447
Número de páginas6
PublicaciónJournal of Experimental Medicine
Volumen141
N.º6
DOI
EstadoPublished - 1975
Publicado de forma externa

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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