Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance

Mounia S. Braza, Patricia Conde, Mercedes Garcia, Isabel Cortegano, Manisha Brahmachary, Venu Pothula, Francois Fay, Peter Boros, Sherry A. Werner, Florent Ginhoux, Willem J.M. Mulder, Jordi Ochando

Resultado de la investigación: Articlerevisión exhaustiva

37 Citas (Scopus)


The colony-stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1-mediated macrophage development remain to be elucidated. Here we demonstrate that neutrophil-derived CSF1 controls macrophage polarization and proliferation, which is necessary for the induction of tolerance. Inhibiting neutrophil production of CSF1 or preventing macrophage proliferation, using targeted nanoparticles loaded with the cell cycle inhibitor simvastatin, abrogates the induction of tolerance. These results provide new mechanistic insights into the developmental requirements of tolerogenic macrophages and identify CSF1 producing neutrophils as critical regulators of the immunological response.

Idioma originalEnglish (US)
Páginas (desde-hasta)1247-1255
Número de páginas9
PublicaciónAmerican Journal of Transplantation
EstadoPublished - may 2018

ASJC Scopus subject areas

  • Transplantation
  • Pharmacology (medical)
  • Immunology and Allergy


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