Near-fatal asthma: Recognition and management

Producción científica: Review articlerevisión exhaustiva

75 Citas (Scopus)


PURPOSE OF REVIEW: Near-fatal asthma continues to be a significant problem despite the decline in overall asthma mortality. The purpose of this review is to discuss recent advances in our understanding of the pathophysiology, diagnosis and treatment of near-fatal asthma. RECENT FINDINGS: Two distinctive phenotypes of near-fatal asthma have been identified: one with eosinophilic inflammation associated with a gradual onset and a slow response to therapy and a second phenotype with neutrophilic inflammation that has a rapid onset and rapid response to therapy. Patients who develop sudden-onset near-fatal asthma seem to have massive allergen exposure and emotional distress. In stable condition, near-fatal asthma frequently cannot be distinguished from mild asthma. Diminished perception of dyspnea plays a relevant role in treatment delay, near-fatal events, and death in patients with severe asthma. Reduced compliance with anti-inflammatory therapy and ingestion of medications or drugs (heroin, cocaine) have been associated with fatal or near-fatal asthma. SUMMARY: Near-fatal asthma is a subtype of asthma with unique risk factors and variable presentation that requires early recognition and aggressive intervention.

Idioma originalEnglish (US)
Páginas (desde-hasta)13-23
Número de páginas11
PublicaciónCurrent Opinion in Pulmonary Medicine
EstadoPublished - ene 2008

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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