Natural products identification for the treatment of chronic inflammation

S. Bhaskaran, K. V. Dileep, C. Sadasivan, J. Padikkala, H. B. Nair

Resultado de la investigación: Chapter

Resumen

Flavonoids embody the most imperative single cluster of phenolics in food; more than 4,000 different types have been recognized. Gossypin, a flavonoid compound originally isolated from the flowers of Hibiscus vitifolius, has been shown to be effective for cleansing kidneys and having antinociceptive effects in traditional/alternative medicine. A wide range of phenolic substances resulting from edible plants have been reported to have noticeable antioxidant and anti-inflammatory actions, which enhance their chemopreventive potential. In this chapter we address the acute and chronic anti-inflammatory properties of gossypin in different in vivo models with inflammation induced by aspirin, carrageenan, formalin, dextran and croton oil. We will also discuss gossypin's antimelanoma properties based on a novel mechanism of action involving the RAF-MEK-ERK pathway. Finally, we will address the possibilities of using gossypin and its rationally designed analogues to develop proprietary drug candidates based on molecular docking studies.

Idioma originalEnglish (US)
Título de la publicación alojadaChronic Inflammation
Subtítulo de la publicación alojadaCauses, Treatment Options and Role in Disease
EditorialNova Science Publishers, Inc.
Páginas217-230
Número de páginas14
ISBN (versión impresa)9781628080940
EstadoPublished - 2013
Publicado de forma externa

ASJC Scopus subject areas

  • Medicine(all)

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