Myc and Max homologs in Drosophila

Peter Gallant, Yuzuru Shiio, Pei Feng Cheng, Susan M. Parkhurst, Robert N. Eisenman

Resultado de la investigación: Articlerevisión exhaustiva

150 Citas (Scopus)

Resumen

The proteins encoded by the myc proto-oncogene family are involved in cell proliferation, apoptosis, differentiation, and neoplasia. Myc acts through dimerization with Max to bind DNA and activate transcription. Homologs of the myc and max genes were cloned from the fruit fly Drosophila melanogaster and their protein products (dMyc and dMax) were shown to heterodimerize, recognize the same DNA sequence as their vertebrate homologs, and activate transcription. The dMyc protein is likely encoded by the Drosophila gene diminutive (dm), a mutation in which results in small body size and female sterility caused by degeneration of the ovaries. These findings indicate a potential role for Myc in germ cell development and set the stage for genetic analysis of Myc and Max.

Idioma originalEnglish (US)
Páginas (desde-hasta)1523-1527
Número de páginas5
PublicaciónScience
Volumen274
N.º5292
DOI
EstadoPublished - nov. 29 1996
Publicado de forma externa

ASJC Scopus subject areas

  • General

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