MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Remi Martin Laberge, Yu Sun, Arturo V. Orjalo, Christopher K. Patil, Adam Freund, Lili Zhou, Samuel C. Curran, Albert R. Davalos, Kathleen A. Wilson-Edell, Su Liu, Chandani Limbad, Marco Demaria, Patrick Li, Gene B. Hubbard, Yuji Ikeno, Martin Javors, Pierre Yves Desprez, Christopher C. Benz, Pankaj Kapahi, Peter S. NelsonJudith Campisi

Producción científica: Articlerevisión exhaustiva

777 Citas (Scopus)

Resumen

The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cellular senescence suppresses cancer by preventing cell proliferation. However, as senescent cells accumulate with age, the senescence-associated secretory phenotype (SASP) can disrupt tissues and contribute to age-related pathologies, including cancer. MTOR inhibition suppressed the secretion of inflammatory cytokines by senescent cells. Rapamycin reduced IL6 and other cytokine mRNA levels, but selectively suppressed translation of the membrane-bound cytokine IL1A. Reduced IL1A diminished NF-κB transcriptional activity, which controls much of the SASP; exogenous IL1A restored IL6 secretion to rapamycin-treated cells. Importantly, rapamycin suppressed the ability of senescent fibroblasts to stimulate prostate tumour growth in mice. Thus, rapamycin might ameliorate age-related pathologies, including late-life cancer, by suppressing senescence-associated inflammation.

Idioma originalEnglish (US)
Páginas (desde-hasta)1049-1061
Número de páginas13
PublicaciónNature Cell Biology
Volumen17
N.º8
DOI
EstadoPublished - ago 6 2015

ASJC Scopus subject areas

  • Cell Biology

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