Mouse models of severe asthma for evaluation of therapeutic cytokine targeting

Ekaterina O. Gubernatorova, Olga A. Namakanova, Alexei V. Tumanov, Marina S. Drutskaya, Sergei A. Nedospasov

Producción científica: Review articlerevisión exhaustiva

15 Citas (Scopus)


Severe asthma is a heterogeneous inflammatory disease of the airways, which requires treatment with high-dose inhaled corticosteroids or their systemic administration, yet often remains uncontrolled despite this therapy. Over the past decades, research efforts into phenotyping of severe asthma and defining the pathological mechanisms of this disease were successful largely due to the development of appropriate animal models. Recent identification of distinct inflammatory patterns of severe asthma endotypes led to novel treatment approaches, including targeting specific cytokines or their receptors with neutralizing antibodies. Here we discuss how different experimental mouse models contributed to generation of clinically relevant findings concerning pathogenesis of severe asthma and to identification of potential targets for biologic therapy.

Idioma originalEnglish (US)
Páginas (desde-hasta)73-83
Número de páginas11
PublicaciónImmunology Letters
EstadoPublished - mar 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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