Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kκB

Neehar Bhatia, Jason R. Herter, Thomas J. Slaga, Serge Y. Fuchs, Vladimir S. Spiegelman

Resultado de la investigación: Articlerevisión exhaustiva

32 Citas (Scopus)

Resumen

NF-kκB transcription factor is activated upon ubiquitination and subsequent proteolysis of its inhibitor IκB. The phosphorylation-dependent ubiquitination is mediated by SCF E3 ubiquitin ligase. In this study, we identified a novel murine F-box/WD40 repeat-containing protein, mHOS (a homologue of HOS/βTrCP2). mHOS efficiently binds Skp1 protein (a 'core' component of SCF ubiquitin ligase), and phosphorylated IκBα. We found that mHOS associates with SCF-ROC1 E3 ubiquitin ligase activity. We have also observed that mHOS is overexpressed in chemically-induced mouse skin tumors, and its overexpression (but not accelerated IκB phosphorylation) coincides with the accelerated degradation of IκB in vivo. The role of mHOS in the constitutive activation of NF-κB in skin carcinogenesis is discussed.

Idioma originalEnglish (US)
Páginas (desde-hasta)1501-1509
Número de páginas9
PublicaciónOncogene
Volumen21
N.º10
DOI
EstadoPublished - feb. 28 2002
Publicado de forma externa

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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