TY - JOUR
T1 - Morphological characteristics of brain aneurysms among age groups
AU - Sanchez, Sebastian
AU - Essibayi, Muhammed Amir
AU - Hickerson, Meredith
AU - Ojeda, Diego J.
AU - Kasab, Sami Al
AU - Yoshimura, Shinichi
AU - Jabbour, Pascal M.
AU - Mascitelli, Justin
AU - Levitt, Michael R.
AU - Cuellar-Saenz, Hugo H.
AU - Brinjikji, Waleed
AU - Spiotta, Alejandro M.
AU - Shaban, Amir
AU - Samaniego, Edgar A.
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023
Y1 - 2023
N2 - Background: Patient's age is an important factor in determining the risk of aneurysm rupture. However, there is limited data on how aneurysm morphology differs among age groups. We studied morphological characteristics of brain aneurysms among age groups in a large cohort. Methods: Aneurysms from the Stroke Thrombectomy and Aneurysm Registry (STAR) were analyzed. The following parameters were included: location, size, neck, width, height, aspect ratio, and regular versus irregular morphology. The risk of rupture presentation was estimated using logistic regression. Results: A total of 1407 unruptured and 607 ruptured saccular aneurysms were included. The most common locations of ruptured aneurysms in patients younger than 70 years-old were the middle cerebral artery (MCA) and the anterior communicating artery (ACOM). The most common location of ruptured aneurysms in patients older than 70 years-old were the posterior communicating artery (PCOM) and ACOM. The size of unruptured aneurysms increased with age (p <.001). Conversely, the size of ruptured aneurysms was similar among age groups (p =.142). Unruptured and ruptured aneurysms became more irregular at presentation with older age (p <.001 and p.025, respectively). Irregular morphology and location were associated with rupture status across all age groups in multivariate regression. Conclusions: Younger patients have small unruptured and ruptured aneurysms, and ruptured aneurysms are mostly located in the MCA and ACOM. Older patients have larger and more irregular unruptured aneurysms, and ruptured aneurysms are mostly located in the PCOM and ACOM. An irregular morphology increases the risk of rupture in all age groups.
AB - Background: Patient's age is an important factor in determining the risk of aneurysm rupture. However, there is limited data on how aneurysm morphology differs among age groups. We studied morphological characteristics of brain aneurysms among age groups in a large cohort. Methods: Aneurysms from the Stroke Thrombectomy and Aneurysm Registry (STAR) were analyzed. The following parameters were included: location, size, neck, width, height, aspect ratio, and regular versus irregular morphology. The risk of rupture presentation was estimated using logistic regression. Results: A total of 1407 unruptured and 607 ruptured saccular aneurysms were included. The most common locations of ruptured aneurysms in patients younger than 70 years-old were the middle cerebral artery (MCA) and the anterior communicating artery (ACOM). The most common location of ruptured aneurysms in patients older than 70 years-old were the posterior communicating artery (PCOM) and ACOM. The size of unruptured aneurysms increased with age (p <.001). Conversely, the size of ruptured aneurysms was similar among age groups (p =.142). Unruptured and ruptured aneurysms became more irregular at presentation with older age (p <.001 and p.025, respectively). Irregular morphology and location were associated with rupture status across all age groups in multivariate regression. Conclusions: Younger patients have small unruptured and ruptured aneurysms, and ruptured aneurysms are mostly located in the MCA and ACOM. Older patients have larger and more irregular unruptured aneurysms, and ruptured aneurysms are mostly located in the PCOM and ACOM. An irregular morphology increases the risk of rupture in all age groups.
KW - Aneurysm
KW - age
KW - morphology
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U2 - 10.1177/15910199231201520
DO - 10.1177/15910199231201520
M3 - Article
C2 - 37715650
AN - SCOPUS:85171268212
SN - 1591-0199
JO - Interventional Neuroradiology
JF - Interventional Neuroradiology
ER -