@article{72cdbc84ea364607ab55adb931dc20e9,
title = "Molecular mechanisms governing reading frame choice of immunoglobulin diversity genes",
abstract = "The key elements of antigen-binding immunoglobulin (Ig) variable regions are primarily encoded by diversity (D(H)) genes. Although D(H) genes can be used in all three reading frames, the majority of peripheral Ig molecules carry a D(H) element in a single reading frame. Here, Frank Raaphorst, C. Raman, Barry Nall and Judy Teale discuss the particular demands imposed by the structure of the antigen-binding site, which determine the choice of reading frame.",
author = "Raaphorst, {Frank M.} and Raman, {C. S.} and Nall, {Barry T.} and Teale, {Judy M.}",
note = "Funding Information: F,M.R.a nd C.S.I~¢ ontribuk,d equally to this stud~,:T he auihor~ would like to thank D, IL~nJ,lmln and R.C. Schelonk~ for critic,ll o~mments on the manu. script and N.M. Lang for assistanct,i n pWl~wattono f the figures. Support for these studies was pmvidLMb y NIH grants AI 19896a nd A133221 to J.T., NIH grant 61432980 k~ B,T,N. and a grant from the Robert Welch foundation tAQ838) to B.T.N.C.S.R. !s grateful to S. Islam, ICRF, UK, for pmvidtng the probwamP REPI.",
year = "1997",
month = jan,
doi = "10.1016/S0167-5699(97)80013-8",
language = "English (US)",
volume = "18",
pages = "37--43",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "1",
}