TY - JOUR
T1 - Moderate and severe periodontitis are positively associated with metabolic syndrome
AU - Gomes-Filho, Isaac Suzart
AU - Balinha, Izadora da S.C.E.
AU - da Cruz, Simone S.
AU - Trindade, Soraya C.
AU - Cerqueira, Eneida de M.M.
AU - Passos-Soares, Johelle de S.
AU - Coelho, Julita Maria F.
AU - Ladeia, Ana Marice T.
AU - Vianna, Maria Isabel P.
AU - Hintz, Alexandre M.
AU - de Santana, Teresinha C.
AU - dos Santos, Pedro P.
AU - Figueiredo, Ana Claúdia M.G.
AU - da Silva, Ivana C.O.
AU - Scannapieco, Frank A.
AU - Barreto, Maurício L.
AU - Loomer, Peter M.
N1 - Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/6
Y1 - 2021/6
N2 - Objective: This study investigated the association between periodontitis severity (exposure) and metabolic syndrome (MetS - outcome), using two criteria for diagnosis of the outcome, since this relationship remains unexplored. Materials and methods: A case-control study was conducted with 870 individuals: 408 with first MetS diagnosis (cases) and 462 without MetS (controls). Participants’ general information was obtained using a questionnaire and laboratory data was collected from medical records. Periodontitis severity criteria followed the Center for Disease Control and Prevention: none, mild, moderate, and severe. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined by logistic regression analysis. Results: Findings showed a positive association between moderate and severe periodontitis and MetS: ORadjusted = 1.64 (95% CI: 1.01 to 2.68) and ORadjusted = 1.94 (95% CI: 1.19 to 3.16), respectively, after adjustment for age, sex, schooling level, smoking habit, and cardiovascular disease. The adjusted measurements showed that among individuals with moderate or severe periodontitis, the probability of having MetS was around two times greater than among those without periodontitis, and that the chance was greater among participants with severe periodontitis than those with moderate periodontitis. Conclusion: An association between the severity of periodontal status and MetS was found, suggesting a possible relationship between the two diseases. Clinical relevance: MetS influences the etiology of cardiovascular diseases, one of the leading causes of mortality worldwide. The findings suggest that the greater the severity of periodontitis, the greater is the association magnitude with MetS. The health professional needs to recognize that the importance of periodontal disease may play in MetS.
AB - Objective: This study investigated the association between periodontitis severity (exposure) and metabolic syndrome (MetS - outcome), using two criteria for diagnosis of the outcome, since this relationship remains unexplored. Materials and methods: A case-control study was conducted with 870 individuals: 408 with first MetS diagnosis (cases) and 462 without MetS (controls). Participants’ general information was obtained using a questionnaire and laboratory data was collected from medical records. Periodontitis severity criteria followed the Center for Disease Control and Prevention: none, mild, moderate, and severe. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined by logistic regression analysis. Results: Findings showed a positive association between moderate and severe periodontitis and MetS: ORadjusted = 1.64 (95% CI: 1.01 to 2.68) and ORadjusted = 1.94 (95% CI: 1.19 to 3.16), respectively, after adjustment for age, sex, schooling level, smoking habit, and cardiovascular disease. The adjusted measurements showed that among individuals with moderate or severe periodontitis, the probability of having MetS was around two times greater than among those without periodontitis, and that the chance was greater among participants with severe periodontitis than those with moderate periodontitis. Conclusion: An association between the severity of periodontal status and MetS was found, suggesting a possible relationship between the two diseases. Clinical relevance: MetS influences the etiology of cardiovascular diseases, one of the leading causes of mortality worldwide. The findings suggest that the greater the severity of periodontitis, the greater is the association magnitude with MetS. The health professional needs to recognize that the importance of periodontal disease may play in MetS.
KW - Diabetes mellitus
KW - Epidemiology
KW - Metabolic syndrome X
KW - Obesity
KW - Periodontitis
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UR - http://www.scopus.com/inward/citedby.url?scp=85096449237&partnerID=8YFLogxK
U2 - 10.1007/s00784-020-03699-2
DO - 10.1007/s00784-020-03699-2
M3 - Article
C2 - 33226499
AN - SCOPUS:85096449237
SN - 1432-6981
VL - 25
SP - 3719
EP - 3727
JO - Clinical Oral Investigations
JF - Clinical Oral Investigations
IS - 6
ER -