TY - GEN
T1 - Modeling competing endogenous RNA regulatory networks in glioblastoma multiforme
AU - Chiu, Yu Chiao
AU - Chuang, Eric Y.
AU - Hsiao, Tzu Hung
AU - Chen, Yidong
PY - 2013
Y1 - 2013
N2 - Recent studies postulated that genes harboring identical microRNA (miRNA) binding sites can crosstalk by competing for a limited pool of the binding miRNAs (the miRNA program), named as the regulation of competing endogenous RNAs (ceRNAs). Incorporating recent biological evidence that ceRNA regulation depends on miRNA program expression levels, we developed, in the present study, a mathematical model for systematically inferring ceRNA regulation that is dependent on expression levels of the miRNA programs from sample-paired mRNA and miRNA expression datasets. Applying the method to analyze glioblastoma datasets, a compact ceRNA regulatory network was constructed. Our data further demonstrated that ceRNA regulation plays an essential role in transient cellular responses to dynamic inter-cellular signals. The findings illuminate mechanism of ceRNA regulation and further provide biological insights into the complex human interactome.
AB - Recent studies postulated that genes harboring identical microRNA (miRNA) binding sites can crosstalk by competing for a limited pool of the binding miRNAs (the miRNA program), named as the regulation of competing endogenous RNAs (ceRNAs). Incorporating recent biological evidence that ceRNA regulation depends on miRNA program expression levels, we developed, in the present study, a mathematical model for systematically inferring ceRNA regulation that is dependent on expression levels of the miRNA programs from sample-paired mRNA and miRNA expression datasets. Applying the method to analyze glioblastoma datasets, a compact ceRNA regulatory network was constructed. Our data further demonstrated that ceRNA regulation plays an essential role in transient cellular responses to dynamic inter-cellular signals. The findings illuminate mechanism of ceRNA regulation and further provide biological insights into the complex human interactome.
KW - competing endogenous RNA
KW - gene regulatory network
KW - glioblastoma multiforme
UR - http://www.scopus.com/inward/record.url?scp=84894593080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894593080&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2013.6732489
DO - 10.1109/BIBM.2013.6732489
M3 - Conference contribution
AN - SCOPUS:84894593080
SN - 9781479913091
T3 - Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
SP - 201
EP - 204
BT - Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
T2 - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
Y2 - 18 December 2013 through 21 December 2013
ER -