Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections

Michelle A. Gill, A. Karolina Palucka, Theresa Barton, Faryal Ghaffar, Hasan Jafri, Jacques Banchereau, Octavio Ramilo

Producción científica: Articlerevisión exhaustiva

125 Citas (Scopus)

Resumen

Background. Respiratory syncytial virus (RSV) is the principal etiologic agent of bronchiolitis and viral pneumonia in infants and young children. Yet, many aspects of its immunopathogenesis are not well understood. Methods. We analyzed the immune cells that are mobilized by RSV and other respiratory viruses, by studying nasal wash samples from children hospitalized with acute viral respiratory infections. Results. RSV mobilizes virtually all blood immune cells, including myeloid dendritic cells (DCs) and plasmacytoid DCs (pDCs), to the nasal mucosa. DCs were also mobilized to the nasal mucosa of children with other viral respiratory infections. The increased number of pDCs in the nasal compartment significantly correlates with RSV load (P = .022), and it is associated with a significant decrease in the number of pDCs in the blood (P = .007). The influx of DCs in the nasal mucosa is not transient, as even higher numbers of both DC subsets were found in respiratory secretions weeks after the acute symptoms of RSV infection had resolved. Immunochemistry analysis of respiratory samples has demonstrated the presence of the RSV fusion protein within HLA-DR-positive cells. Conclusion. Infection with RSV and other respiratory viruses mobilizes DCs to the site of viral entry.

Idioma originalEnglish (US)
Páginas (desde-hasta)1105-1115
Número de páginas11
PublicaciónJournal of Infectious Diseases
Volumen191
N.º7
DOI
EstadoPublished - abr 1 2005
Publicado de forma externa

ASJC Scopus subject areas

  • General Medicine

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