Mitochondrial inner membrane protein, Mic60/mitofilin in mammalian organ protection

Yansheng Feng, Ngonidzashe B. Madungwe, Jean C. Bopassa

Resultado de la investigación: Review articlerevisión exhaustiva

13 Citas (Scopus)


The identification of the mitochondrial contact site and cristae organizing system (MICOS) in the inner mitochondrial membrane shed light on the intricate components necessary for mitochondria to form their signature cristae in which many protein complexes including the electron transport chain are localized. Mic60/mitofilin has been described as the core component for the assembly and maintenance of MICOS, thus controlling cristae morphology, protein transport, mitochondrial DNA transcription, as well as connecting the inner and outer mitochondrial membranes. Although Mic60 homologs are present in many species, mammalian Mic60 is only recently gaining attention as a critical player in several organ systems and diseases with mitochondrial-defect origins. In this review, we summarize what is currently known about the ever-expanding role of Mic60 in mammals, and highlight some new studies pushing the field of mitochondrial cristae organization towards potentially new and exciting therapies targeting this protein.

Idioma originalEnglish (US)
Páginas (desde-hasta)3383-3393
Número de páginas11
PublicaciónJournal of Cellular Physiology
EstadoPublished - abr 2019

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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