TY - CHAP
T1 - Mitochondria, oxidative damage and longevity
T2 - What can comparative biology teach Us?
AU - Shi, Yun
AU - Buffenstein, Rochelle
AU - Vanremmen, Holly
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - The most studied theory of aging is the oxidative stress theory of aging, and evidence supporting or disputing the theory has come primarily from investigations using common model organisms such as C elegans, Drosophila, and laboratory rodent models. However, studies using more non-traditional animal models offer an excellent opportunity to critically evaluate different aging hypotheses. The advantage of studying a broader spectrum of species is that one can significantly expand the amount of information obtained on a wide range of biological phenotypes/traits such as life span, body weight, and metabolic rate. In addition, the ultimate validity of a hypothesis/theory can be more critically tested using as many samples, in this case, species as possible. In this chapter we present evidence regarding different aspects of oxidative stress theory of aging with special emphasis on metabolic rate, reactive oxygen species generation, and oxidative damage to macromolecules. The purpose of the chapter is to initiate the integration of current knowledge and also to inspire readers to consider the advantages and power of using a comparative biology approach to study aging.
AB - The most studied theory of aging is the oxidative stress theory of aging, and evidence supporting or disputing the theory has come primarily from investigations using common model organisms such as C elegans, Drosophila, and laboratory rodent models. However, studies using more non-traditional animal models offer an excellent opportunity to critically evaluate different aging hypotheses. The advantage of studying a broader spectrum of species is that one can significantly expand the amount of information obtained on a wide range of biological phenotypes/traits such as life span, body weight, and metabolic rate. In addition, the ultimate validity of a hypothesis/theory can be more critically tested using as many samples, in this case, species as possible. In this chapter we present evidence regarding different aspects of oxidative stress theory of aging with special emphasis on metabolic rate, reactive oxygen species generation, and oxidative damage to macromolecules. The purpose of the chapter is to initiate the integration of current knowledge and also to inspire readers to consider the advantages and power of using a comparative biology approach to study aging.
KW - Aging
KW - Metabolic rate
KW - Mitochondria
KW - Oxidative damage
KW - Reactive oxygen species
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U2 - 10.1007/978-90-481-3465-6_8
DO - 10.1007/978-90-481-3465-6_8
M3 - Chapter
AN - SCOPUS:80053059977
SN - 9789048134649
SP - 163
EP - 190
BT - The Comparative Biology of Aging
PB - Springer Netherlands
ER -