Mitochondria may mediate prenatal environmental influences in autism spectrum disorder

Richard E. Frye, Janet Cakir, Shannon Rose, Raymond F. Palmer, Christine Austin, Paul Curtin, Manish Arora

Producción científica: Review articlerevisión exhaustiva

23 Citas (Scopus)

Resumen

We propose that the mitochondrion, an essential cellular organelle, mediates the long-term prenatal environmental effects of disease in autism spectrum disorder (ASD). Many prenatal environmental factors which increase the risk of developing ASD influence mitochondria physiol-ogy, including toxicant exposures, immune activation, and nutritional factors. Unique types of mi-tochondrial dysfunction have been associated with ASD and recent studies have linked prenatal environmental exposures to long‐term changes in mitochondrial physiology in children with ASD. A better understanding of the role of the mitochondria in the etiology of ASD can lead to targeted therapeutics and strategies to potentially prevent the development of ASD.

Idioma originalEnglish (US)
Número de artículo218
PublicaciónJournal of Personalized Medicine
Volumen11
N.º3
DOI
EstadoPublished - mar 2021

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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