Resumen
We propose that the mitochondrion, an essential cellular organelle, mediates the long-term prenatal environmental effects of disease in autism spectrum disorder (ASD). Many prenatal environmental factors which increase the risk of developing ASD influence mitochondria physiol-ogy, including toxicant exposures, immune activation, and nutritional factors. Unique types of mi-tochondrial dysfunction have been associated with ASD and recent studies have linked prenatal environmental exposures to long‐term changes in mitochondrial physiology in children with ASD. A better understanding of the role of the mitochondria in the etiology of ASD can lead to targeted therapeutics and strategies to potentially prevent the development of ASD.
Idioma original | English (US) |
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Número de artículo | 218 |
Publicación | Journal of Personalized Medicine |
Volumen | 11 |
N.º | 3 |
DOI | |
Estado | Published - mar 2021 |
ASJC Scopus subject areas
- Medicine (miscellaneous)