TY - GEN
T1 - Mesenchymal cell response to biomaterials is modulated by their maturation state in their lineage
AU - Boyan, Barbara D.
AU - Lohmann, Christoph H.
AU - Dean, David D.
AU - Bonewald, Lynda F.
AU - Cochran, David L.
AU - Schwartz, Zvi
PY - 1999
Y1 - 1999
N2 - Osteoblasts and chondrocytes respond to material surface roughness as well as to chemical composition. The effect of these surface characteristics on chondrocyte response depends on the state of endochondral maturation of the cells. Here, we present data showing that the maturation state of cells in the osteoblastic lineage is also an important variable in their response to material surfaces. Fetal rat calvarial cells (FRCs), MG63 human osteoblast-like osteosarcoma cells, mouse OCT-1 mature osteoblast-like cells, and mouse MLO-Y4 osteocyte-like cells were cultured on cpTi disks with Ra's of 0.5, 4 and 5 mm. Cells expressed their differentiated phenotypes only on rough surfaces in a roughness-dependent manner.
AB - Osteoblasts and chondrocytes respond to material surface roughness as well as to chemical composition. The effect of these surface characteristics on chondrocyte response depends on the state of endochondral maturation of the cells. Here, we present data showing that the maturation state of cells in the osteoblastic lineage is also an important variable in their response to material surfaces. Fetal rat calvarial cells (FRCs), MG63 human osteoblast-like osteosarcoma cells, mouse OCT-1 mature osteoblast-like cells, and mouse MLO-Y4 osteocyte-like cells were cultured on cpTi disks with Ra's of 0.5, 4 and 5 mm. Cells expressed their differentiated phenotypes only on rough surfaces in a roughness-dependent manner.
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M3 - Conference contribution
AN - SCOPUS:0033348642
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 746
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -