Mesenchymal cell response to biomaterials is modulated by their maturation state in their lineage

Barbara D. Boyan, Christoph H. Lohmann, David D. Dean, Lynda F. Bonewald, David L. Cochran, Zvi Schwartz

Resultado de la investigación: Conference contribution

Resumen

Osteoblasts and chondrocytes respond to material surface roughness as well as to chemical composition. The effect of these surface characteristics on chondrocyte response depends on the state of endochondral maturation of the cells. Here, we present data showing that the maturation state of cells in the osteoblastic lineage is also an important variable in their response to material surfaces. Fetal rat calvarial cells (FRCs), MG63 human osteoblast-like osteosarcoma cells, mouse OCT-1 mature osteoblast-like cells, and mouse MLO-Y4 osteocyte-like cells were cultured on cpTi disks with Ra's of 0.5, 4 and 5 mm. Cells expressed their differentiated phenotypes only on rough surfaces in a roughness-dependent manner.

Idioma originalEnglish (US)
Título de la publicación alojadaAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorialIEEE
Número de páginas1
ISBN (versión impresa)0780356756
EstadoPublished - dic 1 1999
EventoProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duración: oct 13 1999oct 16 1999

Serie de la publicación

NombreAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volumen2
ISSN (versión impresa)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CiudadAtlanta, GA, USA
Período10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Huella

Profundice en los temas de investigación de 'Mesenchymal cell response to biomaterials is modulated by their maturation state in their lineage'. En conjunto forman una huella única.

Citar esto