Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide

Miguel A. Pappolla, Melisa Sos, Rawhi A. Omar, Roger J. Bick, Diane L.M. Hickson-Bick, Russel J. Reiter, Spiros Efthimiopoulos, Nickolaos K. Robakis

Resultado de la investigación: Articlerevisión exhaustiva

352 Citas (Scopus)

Resumen

Studies from several laboratories have generated evidence suggesting that oxidative stress is involved in the pathogenesis of Alzheimer's disease (AD). The finding that the amyloid β protein (Aβ) has neurotoxic properties and that such effects are, in part, mediated by free radicals has provided insights into mechanisms of cell death in AD and an avenue to explore new therapeutic approaches. In this study we demonstrate that melatonin, a pineal hormone with recently established antioxidant properties, is remarkably effective in preventing death of cultured neuroblastoma cells as well as oxidative damage and intracellular Ca2+ increases induced by a cytotoxic fragment ofAβ. The effects of melatonin were extremely reproducible and corroborated by multiple quantitative methods, including cell viability studies by confocal laser microscopy, electron microscopy, and measurements of intracellular calcium levels. The importance of this finding is that, in contrast to conventional antioxidants, melatonin has a proposed physiological role in the aging process. Secretion levels of this hormone are decreased in aging and more severely reduced in AD. The reported phenomenon may be of therapeutic relevance in AD.

Idioma originalEnglish (US)
Páginas (desde-hasta)1683-1690
Número de páginas8
PublicaciónJournal of Neuroscience
Volumen17
N.º5
DOI
EstadoPublished - mar. 1 1997

ASJC Scopus subject areas

  • Neuroscience(all)

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