Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage

Russel J. Reiter, D. X. Tan, L. C. Manchester, H. Tamura

Resultado de la investigación: Review articlerevisión exhaustiva

90 Citas (Scopus)

Resumen

Melatonin and its metabolites are potent antioxidants by virtue of their ability to scavenge both oxygen-based and nitrogen-based radicals and intermediates but also as a consequence of their ability to stimulate the activity of antioxidative enzymes. Melatonin also prevents electron leakage from the mitochondrial electron transport chain thereby diminishing free radical generation; this process is referred to as radical avoidance. The fact that melatonin and its metabolites are all efficient radical scavengers indicates that melatonin is a precursor molecule for a variety of intracellular reducing agents. In specific reference to the brain, melatonin also has an advantage over some other antioxidants given that it readily passes through the blood-brain-barrier. This, coupled with the fact that it and its by-products are particularly efficient detoxifiers of reactive species, make these molecules of major importance in protecting the brain from oxidative/nitrosative abuse. This review summarizes the literature on two brain-related situations, i.e., traumatic brain and spinal cord injury and ischemia/reperfusion, and the neurodegenerative disease, amyotrophic lateral sclerosis, where melatonin has been shown to have efficacy in abating neural damage. These, however, are not the only age-associated neurodegenerative states where melatonin has been found to be protective.

Idioma originalEnglish (US)
Páginas (desde-hasta)5-22
Número de páginas18
PublicaciónJournal of Physiology and Pharmacology
Volumen58
N.ºSUPPL. 6
EstadoPublished - dic 2007

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

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