Melatonin and mitochondrial function during ischemia/reperfusion injury

Zhiqiang Ma, Zhenlong Xin, Wencheng Di, Xiaolong Yan, Xiaofei Li, Russel J. Reiter, Yang Yang

Resultado de la investigación: Review articlerevisión exhaustiva

84 Citas (Scopus)


Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine, provides a strong defense against IR injury. Mitochondrion, an organelle for ATP production and a decider for cell fate, has been validated to be a crucial target for melatonin to exert its protection against IR injury. In this review, we first clarify the mechanisms underlying mitochondrial dysfunction during IR and melatonin’s protection of mitochondria under this condition. Thereafter, special focus is placed on the protective actions of melatonin against IR injury in brain, heart, liver, and others. Finally, we explore several potential future directions of research in this area. Collectively, the information compiled here will serve as a comprehensive reference for the actions of melatonin in IR injury identified to date and will hopefully aid in the design of future research and increase the potential of melatonin as a therapeutic agent.

Idioma originalEnglish (US)
Páginas (desde-hasta)3989-3998
Número de páginas10
PublicaciónCellular and Molecular Life Sciences
EstadoPublished - nov 1 2017
Publicado de forma externa

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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