Melatonin, a mediator of electron transfer and repair reactions, acts synergistically with the chain-breaking antioxidants ascorbate, trolox and glutathione

B. Poeggeler, R. J. Reiter, R. Hardeland, E. Sewerynek, D. Melchiorri, L. R. Barlow-Walden

Producción científica: Articlerevisión exhaustiva

94 Citas (Scopus)

Resumen

The antioxidative properties of melatonin, structurally-related indoles and the chain-breaking antioxidants ascorbate, trolox and glutathione were investigated using the radical trapping reagent ABTS (2,2'-azino-bis-3-ethylbenz-thiazoline-6-sulphonic acid). The indole compounds and the phenolic or thiolic antioxidants acted synergistically suppressing the formation of the ABTS cation radical ABTS(*)+ completely when coincubated. Electron-donating indole compounds such as melatonin and chain-breaking antioxidants such as ascorbate can act in concert to provide potent antioxidative protection.

Idioma originalEnglish (US)
Páginas (desde-hasta)87-92
Número de páginas6
PublicaciónNeuroendocrinology Letters
Volumen17
N.º2
EstadoPublished - 1995
Publicado de forma externa

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Physiology (medical)
  • Endocrinology, Diabetes and Metabolism
  • Medicine (miscellaneous)

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