TY - JOUR
T1 - Mechanisms of antidepressant action
T2 - Is onset early or late?
AU - Frazer, Alan
AU - Katz, Martin M.
PY - 2004/12
Y1 - 2004/12
N2 - Earlier studies of the 'onset' of antidepressant action might not have distinguished between the time when improvement first appears from when a substantial response occurs. The application of more refined statistical approaches, together with better assessments of improvement in the behavioral components of the illness, allows onset to be established in absolute terms. Recent studies, using such methodology, consistently reveal that onset of improvement occurs in two weeks or less in ultimate treatment responders.
AB - Earlier studies of the 'onset' of antidepressant action might not have distinguished between the time when improvement first appears from when a substantial response occurs. The application of more refined statistical approaches, together with better assessments of improvement in the behavioral components of the illness, allows onset to be established in absolute terms. Recent studies, using such methodology, consistently reveal that onset of improvement occurs in two weeks or less in ultimate treatment responders.
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U2 - 10.1016/j.ddmec.2004.11.019
DO - 10.1016/j.ddmec.2004.11.019
M3 - Review article
AN - SCOPUS:23744505973
SN - 1740-6765
VL - 1
SP - 429
EP - 433
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
IS - 4
ER -