Mechanism of Hypocalcemic Effect of Inorganic Phosphate

The plasma calcium-lowering effect of phosphate administration has been known since 1932,1 although its use in the management of hypercalcemic crisis has only recently become accepted.23 However, the exact fate of calcium removed from the blood is still uncertain. There are several theories — namely, theory of decreased bone resorption12 and theory of increased bone formation.4. Extraskeletal deposition of calcium was suggested by Hebert et al.5 as another theoretical mechanism, but the exact anatomic site was obscure. Our experimental observations67 with radioisotopes of strontium and calcium in animals suggest that phosphate forms presumably a colloid of.