TY - JOUR
T1 - Mechanical hypernociception in experimental autoimmune encephalomyelitis
AU - Rodrigues, David Henrique
AU - Sachs, Daniela
AU - Teixeira, Antonio Lucio
PY - 2009/3
Y1 - 2009/3
N2 - Background: Pain is an important clinical manifestation in multiple sclerosis (MS) patients, though it has been neglected in clinical and experimental researches. Objective: To investigate the nociceptive response in MOG35-55 experimental autoimmune encephalomyelitis (EAE)-induced mice. Method: EAE was induced in 8 to 10 week old C57BL/6 female mice with an emulsion of MOG35-55, Complete Freund Adjuvant, Mycobacterium tuberculosis H37 RA and pertussis toxin. Nociception was evaluated by the von Frey filaments method. A clinical scale ranging from 0 to 15 was used to assess motor impairment. Results: Clinical evidence of disease started at day 10 and peaked at day 14 after immunization. Thereafter, there was no worsening of symptoms until day 26. The EAE-induced mice presented reduced pressure threshold at days 7th and 10th after immunization and before the onset of clinical motor signs. Conclusion: The hypemociception found validates MOG35-55 EAE as a model for the study of pain in multiple sclerosis.
AB - Background: Pain is an important clinical manifestation in multiple sclerosis (MS) patients, though it has been neglected in clinical and experimental researches. Objective: To investigate the nociceptive response in MOG35-55 experimental autoimmune encephalomyelitis (EAE)-induced mice. Method: EAE was induced in 8 to 10 week old C57BL/6 female mice with an emulsion of MOG35-55, Complete Freund Adjuvant, Mycobacterium tuberculosis H37 RA and pertussis toxin. Nociception was evaluated by the von Frey filaments method. A clinical scale ranging from 0 to 15 was used to assess motor impairment. Results: Clinical evidence of disease started at day 10 and peaked at day 14 after immunization. Thereafter, there was no worsening of symptoms until day 26. The EAE-induced mice presented reduced pressure threshold at days 7th and 10th after immunization and before the onset of clinical motor signs. Conclusion: The hypemociception found validates MOG35-55 EAE as a model for the study of pain in multiple sclerosis.
KW - Experimental autoimmune encephalomyelitis
KW - Hyperalgesia
KW - Mechanical hypernociception
KW - Multiple sclerosis
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U2 - 10.1590/S0004-282X2009000100019
DO - 10.1590/S0004-282X2009000100019
M3 - Article
C2 - 19330217
AN - SCOPUS:66149169785
SN - 0004-282X
VL - 67
SP - 78
EP - 81
JO - Arquivos de neuro-psiquiatria
JF - Arquivos de neuro-psiquiatria
IS - 1
ER -