Measurement of osteocyte deformation resulting from fluid flow induced shear stress

Daniel P. Nicolella; Eugene Sprague; Lynda Bonewald

Measurement of osteocyte deformation resulting from fluid flow induced shear stress

Daniel P. Nicolella, Eugene Sprague, Lynda Bonewald

Department of Medicine

Producción científica: Conference contribution

1 Cita (Scopus)

Resumen

It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm². Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid flow induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

Idioma original	English (US)
Título de la publicación alojada	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Editorial	ASME
Páginas	163-164
Número de páginas	2
Volumen	43
ISBN (versión impresa)	0791816400
Estado	Published - 1999
Evento	Advances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition) - Nashville, TN, USA Duración: nov 14 1999 → nov 19 1999

Other

Other	Advances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition)
Ciudad	Nashville, TN, USA
Período	11/14/99 → 11/19/99

ASJC Scopus subject areas

General Engineering

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Nicolella, DP, Sprague, E & Bonewald, L 1999, Measurement of osteocyte deformation resulting from fluid flow induced shear stress. En American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 43, ASME, pp. 163-164, Advances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition), Nashville, TN, USA, 11/14/99.

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AB - It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid flow induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

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PB - ASME

T2 - Advances in Bioengineering - 1999 (The ASME International Mechanical Engineering Congress and Exposition)

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ER -

Measurement of osteocyte deformation resulting from fluid flow induced shear stress

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ASJC Scopus subject areas

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