Resumen
Objective: Pre-pregnancy or first trimester biomarkers predicting preterm delivery are lacking. The purpose of this study was to determine whether maternal H-antigen (secretor status) is a potential biomarker for preterm delivery. Methods: This cohort study examined maternal saliva samples and birth data gathered by the National Children’s Study Vanguard pilot phase (2009–2014) and included 300 women who were ≥18 years old and provided birth data and saliva samples. The maternal secretor status phenotype was determined by quantifying H-antigen in saliva using enzyme-linked immunoassay. Mothers were stratified by secretor status and multivariable analysis estimated adjusted associations with preterm delivery. Results: Maternal lack of H-antigen production was an independent risk factor for preterm delivery after adjusting for known confounders (aOR 4.53; 95% CI: 1.74, 11.81; P = 0.002). Conclusions: Maternal H-antigen may be a biomarker identifying women at-risk for preterm delivery. Prospective cohort studies validating these findings are needed.
Idioma original | English (US) |
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Páginas (desde-hasta) | 2147-2155 |
Número de páginas | 9 |
Publicación | Journal of Perinatology |
Volumen | 41 |
N.º | 9 |
DOI | |
Estado | Published - sept 2021 |
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Pediatrics, Perinatology, and Child Health