Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone

P. A. Lalley; A. Y. Sakaguchi; R. L. Eddy; N. H. Honey; G. I. Bell; L. P. Shen; W. J. Rutter; J. W. Jacobs; G. Heinrich; W. W. Chin; S. L. Naylor

doi:10.1159/000132350

Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone

P. A. Lalley
, A. Y. Sakaguchi
, R. L. Eddy
, N. H. Honey
, G. I. Bell
, L. P. Shen
, W. J. Rutter
, J. W. Jacobs
, G. Heinrich
, W. W. Chin
, S. L. Naylor

Department of Cell Systems & Anatomy

Producción científica: Article › revisión exhaustiva

36 Citas (Scopus)

Resumen

Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc), and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRI fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRI fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.

Idioma original	English (US)
Páginas (desde-hasta)	92-97
Número de páginas	6
Publicación	Cytogenetics and Cell Genetics
Volumen	44
N.º	2-3
DOI	https://doi.org/10.1159/000132350
Estado	Published - 1987

ASJC Scopus subject areas

Genetics
Cell Biology

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title = "Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone",

abstract = "Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc), and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRI fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRI fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.",

author = "Lalley, \{P. A.\} and Sakaguchi, \{A. Y.\} and Eddy, \{R. L.\} and Honey, \{N. H.\} and Bell, \{G. I.\} and Shen, \{L. P.\} and Rutter, \{W. J.\} and Jacobs, \{J. W.\} and G. Heinrich and Chin, \{W. W.\} and Naylor, \{S. L.\}",

year = "1987",

doi = "10.1159/000132350",

language = "English (US)",

volume = "44",

pages = "92--97",

journal = "Cytogenetics and Cell Genetics",

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publisher = "S. Karger AG",

number = "2-3",

}

TY - JOUR

T1 - Mapping polypeptide hormone genes in the mouse

T2 - Somatostatin, glucagon, calcitonin, and parathyroid hormone

AU - Lalley, P. A.

AU - Sakaguchi, A. Y.

AU - Eddy, R. L.

AU - Honey, N. H.

AU - Bell, G. I.

AU - Shen, L. P.

AU - Rutter, W. J.

AU - Jacobs, J. W.

AU - Heinrich, G.

AU - Chin, W. W.

AU - Naylor, S. L.

PY - 1987

Y1 - 1987

N2 - Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc), and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRI fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRI fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.

AB - Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc), and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRI fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRI fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.

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UR - https://www.scopus.com/pages/publications/0023189840#tab=citedBy

U2 - 10.1159/000132350

DO - 10.1159/000132350

M3 - Article

C2 - 2882956

AN - SCOPUS:0023189840

SN - 0301-0171

VL - 44

SP - 92

EP - 97

JO - Cytogenetics and Cell Genetics

JF - Cytogenetics and Cell Genetics

IS - 2-3

ER -

Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone

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ASJC Scopus subject areas

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