Mapping Lupus Susceptibility Genes in the NZM2410 Mouse Model

Resultado de la investigación: Chapter

27 Citas (Scopus)

Resumen

Considerable efforts have been deployed over the years to decipher the genetic basis of systemic lupus erythematosus (SLE). The NZM2410 strain is murine model in which the genetic analysis of SLE is the most advanced. NZM2410 studies have shown that, as in SLE patients, lupus susceptibility is achieved by the coexpression of many susceptibility alleles, each of which with a small contribution to the overall disease phenotype. This mouse model has also revealed the critical role played by gene-gene interactions, which are believed to be an essential contribution to human SLE heritability, although it has been much more difficult to characterize. We have now reached a phase in which NZM2410 susceptibility genes have been identified, all them novel in their association with lupus or even with immune functions. Ongoing studies geared at understanding how these genes impact immune tolerance and interact with each other in the mouse, and their impact on the human immune system or target organs, will undoubtedly lead to important discovery for a better understanding on the disease and potential identification of therapeutic targets.

Idioma originalEnglish (US)
Título de la publicación alojadaAdvances in Immunology
EditorialAcademic Press Inc.
Páginas113-139
Número de páginas27
DOI
EstadoPublished - 2012
Publicado de forma externa

Serie de la publicación

NombreAdvances in Immunology
Volumen115
ISSN (versión impresa)0065-2776
ISSN (versión digital)1557-8445

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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