Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia

Satyajit Mohite; Salvina M. de Campos-Carli; Natalia P. Rocha; Shiva Sharma; Aline S. Miranda; Izabela G. Barbosa; Joao V. Salgado; Ana Cristina Simoes-e-Silva; Antonio L. Teixeira

doi:10.1016/j.schres.2018.06.023

Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia

Satyajit Mohite, Salvina M. de Campos-Carli, Natalia P. Rocha, Shiva Sharma, Aline S. Miranda, Izabela G. Barbosa, Joao V. Salgado, Ana Cristina Simoes-e-Silva, Antonio L. Teixeira

Producción científica: Article › revisión exhaustiva

23 Citas (Scopus)

Resumen

This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.

Idioma original	English (US)
Páginas (desde-hasta)	50-54
Número de páginas	5
Publicación	Schizophrenia research
Volumen	202
DOI	https://doi.org/10.1016/j.schres.2018.06.023
Estado	Published - dic 2018
Publicado de forma externa	Sí

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2018.06.023

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title = "Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia",

abstract = "This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.",

keywords = "Angiotensin, Angiotensin-converting enzyme, Cognition, Renin-angiotensin system (RAS), Schizophrenia",

author = "Satyajit Mohite and {de Campos-Carli}, {Salvina M.} and Rocha, {Natalia P.} and Shiva Sharma and Miranda, {Aline S.} and Barbosa, {Izabela G.} and Salgado, {Joao V.} and Simoes-e-Silva, {Ana Cristina} and Teixeira, {Antonio L.}",

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year = "2018",

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doi = "10.1016/j.schres.2018.06.023",

language = "English (US)",

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AU - Mohite, Satyajit

AU - de Campos-Carli, Salvina M.

AU - Rocha, Natalia P.

AU - Sharma, Shiva

AU - Miranda, Aline S.

AU - Barbosa, Izabela G.

AU - Salgado, Joao V.

AU - Simoes-e-Silva, Ana Cristina

AU - Teixeira, Antonio L.

PY - 2018/12

Y1 - 2018/12

N2 - This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.

AB - This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1–7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th–75th percentiles) = 434.79 (341.15–524.02) vs. 508.49 (396.34–608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1–7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.

KW - Angiotensin

KW - Angiotensin-converting enzyme

KW - Cognition

KW - Renin-angiotensin system (RAS)

KW - Schizophrenia

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SP - 50

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JO - Schizophrenia research

JF - Schizophrenia research

ER -

Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia

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ASJC Scopus subject areas

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