Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice

M. M. Miller; D. Joshi; R. B. Billiar; J. F. Nelson

doi:10.1016/0197-4580(90)90548-E

Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice

M. M. Miller, D. Joshi, R. B. Billiar, J. F. Nelson

Producción científica: Article › revisión exhaustiva

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Resumen

This study reports the quantitative immunohistochemical distribution of luteinizing hormone-releasing hormone (LH-RH) neurons within rostral forebrain of young (5-6 month) and old (26-28 month) C57BL/6J mouse. Old mice demonstrated a significant (18%) loss of LH-RH-containing neurons (p < 0.001, ANOVA). The most striking losses involved the preoptic area (24%) and more rostral regions (26%). The presence of pituitary or mesenteric tumors in order mice did not affect the density of LH-RH neurons. These observations indicate that LH-RH neurons comprise part of the neuronal population previously reported to be reduced in the preoptic area of older mice (4).

Idioma original	English (US)
Páginas (desde-hasta)	217-221
Número de páginas	5
Publicación	Neurobiology of Aging
Volumen	11
N.º	3
DOI	https://doi.org/10.1016/0197-4580(90)90548-E
Estado	Published - 1990
Publicado de forma externa	Sí

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Aging
General Neuroscience
Developmental Biology

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title = "Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice",

abstract = "This study reports the quantitative immunohistochemical distribution of luteinizing hormone-releasing hormone (LH-RH) neurons within rostral forebrain of young (5-6 month) and old (26-28 month) C57BL/6J mouse. Old mice demonstrated a significant (18%) loss of LH-RH-containing neurons (p < 0.001, ANOVA). The most striking losses involved the preoptic area (24%) and more rostral regions (26%). The presence of pituitary or mesenteric tumors in order mice did not affect the density of LH-RH neurons. These observations indicate that LH-RH neurons comprise part of the neuronal population previously reported to be reduced in the preoptic area of older mice (4).",

keywords = "Aging, Hypothalamus, Immunocytochemistry, Luteinizing-hormone releasing hormone, Mouse, Preoptic area",

author = "Miller, {M. M.} and D. Joshi and Billiar, {R. B.} and Nelson, {J. F.}",

year = "1990",

doi = "10.1016/0197-4580(90)90548-E",

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AU - Miller, M. M.

AU - Joshi, D.

AU - Billiar, R. B.

AU - Nelson, J. F.

PY - 1990

Y1 - 1990

N2 - This study reports the quantitative immunohistochemical distribution of luteinizing hormone-releasing hormone (LH-RH) neurons within rostral forebrain of young (5-6 month) and old (26-28 month) C57BL/6J mouse. Old mice demonstrated a significant (18%) loss of LH-RH-containing neurons (p < 0.001, ANOVA). The most striking losses involved the preoptic area (24%) and more rostral regions (26%). The presence of pituitary or mesenteric tumors in order mice did not affect the density of LH-RH neurons. These observations indicate that LH-RH neurons comprise part of the neuronal population previously reported to be reduced in the preoptic area of older mice (4).

AB - This study reports the quantitative immunohistochemical distribution of luteinizing hormone-releasing hormone (LH-RH) neurons within rostral forebrain of young (5-6 month) and old (26-28 month) C57BL/6J mouse. Old mice demonstrated a significant (18%) loss of LH-RH-containing neurons (p < 0.001, ANOVA). The most striking losses involved the preoptic area (24%) and more rostral regions (26%). The presence of pituitary or mesenteric tumors in order mice did not affect the density of LH-RH neurons. These observations indicate that LH-RH neurons comprise part of the neuronal population previously reported to be reduced in the preoptic area of older mice (4).

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KW - Hypothalamus

KW - Immunocytochemistry

KW - Luteinizing-hormone releasing hormone

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Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice

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