Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice

M. M. Miller, D. Joshi, R. B. Billiar, J. F. Nelson

Producción científica: Articlerevisión exhaustiva

38 Citas (Scopus)

Resumen

This study reports the quantitative immunohistochemical distribution of luteinizing hormone-releasing hormone (LH-RH) neurons within rostral forebrain of young (5-6 month) and old (26-28 month) C57BL/6J mouse. Old mice demonstrated a significant (18%) loss of LH-RH-containing neurons (p < 0.001, ANOVA). The most striking losses involved the preoptic area (24%) and more rostral regions (26%). The presence of pituitary or mesenteric tumors in order mice did not affect the density of LH-RH neurons. These observations indicate that LH-RH neurons comprise part of the neuronal population previously reported to be reduced in the preoptic area of older mice (4).

Idioma originalEnglish (US)
Páginas (desde-hasta)217-221
Número de páginas5
PublicaciónNeurobiology of Aging
Volumen11
N.º3
DOI
EstadoPublished - 1990
Publicado de forma externa

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Aging
  • General Neuroscience
  • Developmental Biology

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