Lipid Metabolism and Lipidomics Applications in Cancer Research

Meixia Pan, Chao Qin, Xianlin Han

Producción científica: Chapter

18 Citas (Scopus)

Resumen

Lipids are the critical components of cellular and plasma membrane, which constitute an impermeable barrier of cellular compartments, and play important roles on numerous cellular processes including cell growth, proliferation, differentiation, and signaling. Alterations in lipid metabolism have been implicated in the development and progression of cancers. However, unlike other biomolecules, the diversity in the structures and characteristics of lipid species results in the limited understanding of their metabolic alterations in cancers. Lipidomics is an emerging discipline that studies lipids in a large scale based on analytical chemistry principles and technological tools. Multidimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) uses direct infusion to avoid difficulties from alterations in concentration, chromatographic anomalies, and ion-pairing alterations to improve resolution and achieve rapid and accurate qualitative and quantitative analysis. In this chapter, lipids and lipid metabolism relevant to cancer research are introduced, followed by a brief description of MDMS-SL and other shotgun lipidomics techniques and some applications for cancer research.

Idioma originalEnglish (US)
Título de la publicación alojadaAdvances in Experimental Medicine and Biology
EditorialSpringer
Páginas1-24
Número de páginas24
DOI
EstadoPublished - 2021

Serie de la publicación

NombreAdvances in Experimental Medicine and Biology
Volumen1316
ISSN (versión impresa)0065-2598
ISSN (versión digital)2214-8019

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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