Lexical retrieval in discourse: An early indicator of Alzheimer's dementia

Seija Pekkala, Debra Wiener, Jayandra J. Himali, Alexa S. Beiser, Loraine K. Obler, Yulin Liu, Ann McKee, Sanford Auerbach, Sudha Seshadri, Philip A. Wolf, Rhoda Au

Producción científica: Articlerevisión exhaustiva

30 Citas (Scopus)


We examined the progression of lexical-retrieval deficits in individuals with neuropathologically determined Alzheimer's disease (AD; n=23) and a comparison group without criteria for AD (n=24) to determine whether linguistic changes were a significant marker of the disease. Our participants underwent multiple administrations of a neuropsychological battery, with initial administration occurring on average 16 years prior to death. The battery included the Boston Naming Test (BNT), a letter fluency task (FAS) and written description of the Cookie Theft Picture (CTP). Repeated measures analysis revealed that the AD-group showed progressively greater decline in FAS and CTP lexical performance than the comparison group. Cross-sectional time-specific group comparisons indicated that the CTP differentiated performance between the two groups at 7-9 years prior to death and FAS and BNT only at 2-4 years. These results suggest that lexical-retrieval deficits in written discourse serve as an early indicator of AD.

Idioma originalEnglish (US)
Páginas (desde-hasta)905-921
Número de páginas17
PublicaciónClinical Linguistics and Phonetics
EstadoPublished - 2013
Publicado de forma externa

ASJC Scopus subject areas

  • Speech and Hearing
  • Language and Linguistics
  • Linguistics and Language


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