Resumen
The pathogenesis of Charcot neuroarthropathy is unclear. To investigate the possibility that decreased levels of calcitonin gene-related peptide and endothelial nitric oxide synthase are involved in the process, we studied bone samples from healthy subjects (n = 4), subjects with diabetic neuropathy (n = 4), and subjects with Charcot neuroarthropathy (n = 4). A statistically significant difference was found in endothelial nitric oxide synthase expression between bone specimens in patients with diabetic neuropathy, Charcot neuroarthropathy, and normal bone (P = .008). A trend toward calcitonin gene-related peptide intensification was observed in normal bone as compared to diabetic neuropathy and Charcot neuroarthropathy bone specimens, but it did not reached statistical significance (P = .23). This pilot study suggests that abnormal calcitonin gene-related peptide and endothelial nitric oxide synthase activity may play a role in the development of Charcot neuroarthropathy. Level of Clinical Evidence: 4.
Idioma original | English (US) |
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Páginas (desde-hasta) | 424-429 |
Número de páginas | 6 |
Publicación | Journal of Foot and Ankle Surgery |
Volumen | 47 |
N.º | 5 |
DOI | |
Estado | Published - sept 2008 |
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine