Leptin increases uncoupling protein expression and energy expenditure

Philip J. Scarpace, Michael Matheny, Brad H. Pollock, Nihal Tümer

Resultado de la investigación: Articlerevisión exhaustiva

361 Citas (Scopus)


In ob/ob mice, leptin increases energy expenditure and sympathetic outflow to brown adipose tissue (BAT). To test whether the mechanism of increased energy expenditure may involve increased thermogenesis in BAT, we acclimated normal rats to thermoneutrality for 2 wk followed by leptin administration for 1 wk. Some rats were food restricted for 1 wk to the level of food consumption in the leptin-treated ad libitum-fed rats, and the same rats were both food restricted and administered leptin for a second week. We examined oxygen consumption and uncoupling protein (UCP) expression in BAT. Leptin increased oxygen consumption after the 5th and 6th days in ad libitum- fed rats and after the 4th, 5th, and 6th days in food-restricted rats. Leptin increased BAT UCP mRNA levels greater than twofold in both ad libitum-fed and food-restricted rats. These data demonstrate a leptin-induced increase in energy expenditure in nonmutant rodents and suggest that one mechanism by which leptin increases energy expenditure is through increased thermogenesis in BAT, including increased expression of UCP.

Idioma originalEnglish (US)
Páginas (desde-hasta)E226-E230
PublicaciónAmerican Journal of Physiology - Endocrinology and Metabolism
N.º1 36-1
EstadoPublished - jul. 1997
Publicado de forma externa

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


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