Kidney pericytes: A novel therapeutic target in interstitial fibrosis

Stuart W. Smith, Claudia Schrimpf, Dipen J. Parekh, Manjeri Venkatachalam, Jeremy S. Duffield

Resultado de la investigación: Review articlerevisión exhaustiva

17 Citas (Scopus)

Resumen

Chronic Kidney Disease affects approximately 8% of the population and contributes considerably to premature morbidity and mortality. Recently reported studies have highlighted an important role for resident microvascular pericytes in the pathogenesis of kidney fibrosis. Pericytes are emerging as the predominant source of the activated, matrix depositing, stromal cell population seen in progressive fibrosis. Further, pericyte activation leads to their detachment from the vasculature, triggers unstable microvasculature and leads to rarefaction. Strategies to modulate pericyte function in these processes are therefore therapeutically attractive. In this review we will first describe our current understanding of the structure and function of the pericyte and the role these cells play in angiogenesis and the pathogenesis of renal fibrosis. Novel therapeutic approaches targeting pericytes in murine models of renal disease will then be considered.

Idioma originalEnglish (US)
Páginas (desde-hasta)1503-1514
Número de páginas12
PublicaciónHistology and Histopathology
Volumen27
N.º12
EstadoPublished - abr. 2012

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Huella

Profundice en los temas de investigación de 'Kidney pericytes: A novel therapeutic target in interstitial fibrosis'. En conjunto forman una huella única.

Citar esto