Ketamine protects cultured neocortical neurons from hypoxic injury

John Weiss; Mark P. Goldberg; Dennis W. Choi

doi:10.1016/0006-8993(86)91447-2

Ketamine protects cultured neocortical neurons from hypoxic injury

John Weiss
, Mark P. Goldberg
, Dennis W. Choi

Producción científica: Article › revisión exhaustiva

121 Citas (Scopus)

Resumen

The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

Idioma original	English (US)
Páginas (desde-hasta)	186-190
Número de páginas	5
Publicación	Brain Research
Volumen	380
N.º	1
DOI	https://doi.org/10.1016/0006-8993(86)91447-2
Estado	Published - ago 13 1986
Publicado de forma externa	Sí

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Ketamine protects cultured neocortical neurons from hypoxic injury",

abstract = "The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.",

keywords = "cell culture, cell death, cyanide, glutamate, hypoxia, ketamine",

author = "John Weiss and Goldberg, \{Mark P.\} and Choi, \{Dennis W.\}",

note = "Funding Information: Wills and Hereditary Disease Foundations, and by a Hartford Fellowship from the John A. Hartford Foundation (to D.W.C.). Funding Information: Yokoyama for expert assistance with cell cultures. Ketamine was a kind gift from Warner-Lambert. This research was supported by Grant NS21628 from the National Institute of Health, grants from the",

year = "1986",

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doi = "10.1016/0006-8993(86)91447-2",

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AU - Goldberg, Mark P.

AU - Choi, Dennis W.

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PY - 1986/8/13

Y1 - 1986/8/13

N2 - The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

AB - The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

KW - cell culture

KW - cell death

KW - cyanide

KW - glutamate

KW - hypoxia

KW - ketamine

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UR - https://www.scopus.com/pages/publications/0022458644#tab=citedBy

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AN - SCOPUS:0022458644

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EP - 190

JO - Brain Research

JF - Brain Research

IS - 1

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Ketamine protects cultured neocortical neurons from hypoxic injury

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ASJC Scopus subject areas

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