Keep the traffic moving: Mechanism of the Hsp70 motor

Rui J Sousa; Eileen M. Lafer

doi:10.1111/j.1600-0854.2006.00497.x

Keep the traffic moving: Mechanism of the Hsp70 motor

Rui J Sousa, Eileen M. Lafer

Department of Biochemistry & Structural Biology

Producción científica: Review article › revisión exhaustiva

34 Citas (Scopus)

Resumen

Hsp70s are ubiquitous chaperones that use ATP hydrolysis to drive a variety of protein processing reactions, including a number of steps in protein trafficking. Recent studies have shed light on how ATP might generate conformational changes in an Hsp70 molecule and how such changes might be harnessed to drive processes as diverse as protein import into subcellular organelles and uncoating of clathrin-coated vesicles.

Idioma original	English (US)
Páginas (desde-hasta)	1596-1603
Número de páginas	8
Publicación	Traffic
Volumen	7
N.º	12
DOI	https://doi.org/10.1111/j.1600-0854.2006.00497.x
Estado	Published - dic 2006

ASJC Scopus subject areas

Genetics
Molecular Biology
Structural Biology
Biochemistry
Cell Biology

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abstract = "Hsp70s are ubiquitous chaperones that use ATP hydrolysis to drive a variety of protein processing reactions, including a number of steps in protein trafficking. Recent studies have shed light on how ATP might generate conformational changes in an Hsp70 molecule and how such changes might be harnessed to drive processes as diverse as protein import into subcellular organelles and uncoating of clathrin-coated vesicles.",

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author = "Sousa, {Rui J} and Lafer, {Eileen M.}",

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AU - Lafer, Eileen M.

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KW - Clathrin

KW - Coated vesicles

KW - Hsc70

KW - Hsp70

KW - Motor protein

KW - Protein import

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Keep the traffic moving: Mechanism of the Hsp70 motor

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