Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma

Daruka Mahadevan; Gregory C. Rogers

doi:10.1016/j.trecan.2020.03.009

Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma

Daruka Mahadevan, Gregory C. Rogers

Producción científica: Short survey › revisión exhaustiva

3 Citas (Scopus)

Resumen

Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.

Idioma original	English (US)
Páginas (desde-hasta)	627-630
Número de páginas	4
Publicación	Trends in Cancer
Volumen	6
N.º	8
DOI	https://doi.org/10.1016/j.trecan.2020.03.009
Estado	Published - ago 2020

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2020.03.009

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title = "Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma",

abstract = "Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.",

keywords = "aneuploidy, drug resistance, polyploidy, tetraploidy, tumor evolution",

author = "Daruka Mahadevan and Rogers, {Gregory C.}",

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T1 - Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma

AU - Mahadevan, Daruka

AU - Rogers, Gregory C.

PY - 2020/8

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N2 - Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.

AB - Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.

KW - aneuploidy

KW - drug resistance

KW - polyploidy

KW - tetraploidy

KW - tumor evolution

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DO - 10.1016/j.trecan.2020.03.009

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JO - Trends in Cancer

JF - Trends in Cancer

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ER -

Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma

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