Isolation and differentiation of self-renewable neural stem cells from marmoset-induced pluripotent stem cells

Hyenjong Hong, Gourav Roy-Choudhury, Jeffrey Kim, Marcel M. Daadi

Producción científica: Chapter

Resumen

Neural stem cells (NSCs) are multipotent and self-renewing precursor cells that give rise to all cell types of the central nervous system (CNS). They can be used for modeling CNS in vitro, for developmental studies and for cell replacement therapies. NSCs can be derived from pluripotent stem cells through differentiation using specific growth factors. Nonhuman primates (NHP) are critical preclinical models for translational research. Induced pluripotent stem cells (iPSCs) can be generated from NHP for the purposes of allogenic or autologous cell replacement studies. Here, we describe the derivation of NSCs from NHP iPSCs.

Idioma originalEnglish (US)
Título de la publicación alojadaMethods in Molecular Biology
EditorialHumana Press
Páginas199-204
Número de páginas6
DOI
EstadoPublished - 2019

Serie de la publicación

NombreMethods in Molecular Biology
Volumen1919
ISSN (versión impresa)1064-3745

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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