Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF-α and ROS

Qian Zhang, Linlin Zhu, Gang Wang, Ye Zhao, Na Xiong, Hegang Bao, Wensen Jin

Producción científica: Articlerevisión exhaustiva

13 Citas (Scopus)

Resumen

The skin-associated chemokine CCL27 and its receptor CCR10 mediate the immune response of skin-homing T cells. The CCL27 secreted from keratinocytes was reportedly involved in inflammatory skin diseases such as atopic dermatitis, contact dermatitis, and psoriasis. However, whether ionizing radiation increases the levels of CCL27 secretion still remains unclear. In HaCaT cells, a human keratinocyte cell line, CCL27 secretion was markedly increased after X-ray irradiation. We further found that irradiation boosted the generation of reactive oxygen species (ROS), which was concomitant with the release of tumor necrosis factor-alpha (TNF-α). Moreover, alteration of ROS in irradiated HaCaT cells correlated with TNF-α secretion, indicating a positive loop of TNF-α secretion and ROS generation. This positive loop regulated the secretion of CCL27 from irradiated cells. We therefore concluded that the cross talk between TNF-α and ROS after keratinocytes was exposed to radiation, triggered CCL27 secretion for subsequent inflammation response.

Idioma originalEnglish (US)
Número de artículoe21868
PublicaciónJournal of Biochemical and Molecular Toxicology
Volumen31
N.º3
DOI
EstadoPublished - mar 1 2017
Publicado de forma externa

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Toxicology

Huella

Profundice en los temas de investigación de 'Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF-α and ROS'. En conjunto forman una huella única.

Citar esto