@article{f8c8454a21e943f3a728f8bc9a235837,
title = "Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids",
abstract = "Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability. Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), had higher affinity at opioid receptors than at adrenergic receptors while the vice versa was observed for corynantheidine. The observed polypharmacology of kratom alkaloids may support its utilization to treat opioid use disorder and withdrawal.",
author = "Samuel Obeng and Kamble, {Shyam H.} and Reeves, {Morgan E.} and Restrepo, {Luis F.} and Avi Patel and Mira Behnke and Chear, {Nelson J.Y.} and Surash Ramanathan and Abhisheak Sharma and Francisco Le{\'o}n and Takato Hiranita and Avery, {Bonnie A.} and Mcmahon, {Lance R} and McCurdy, {Christopher R.}",
note = "Funding Information: This work was supported by National Institute on Drug Abuse grants DA47855 and DA48353. This work was also supported by funds from the State of Florida and a generous gift through the University of Florida Foundation. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",
year = "2020",
month = jan,
day = "9",
doi = "10.1021/acs.jmedchem.9b01465",
language = "English (US)",
volume = "63",
pages = "433--439",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "1",
}