Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

Samuel Obeng, Shyam H. Kamble, Morgan E. Reeves, Luis F. Restrepo, Avi Patel, Mira Behnke, Nelson J.Y. Chear, Surash Ramanathan, Abhisheak Sharma, Francisco León, Takato Hiranita, Bonnie A. Avery, Lance R Mcmahon, Christopher R. McCurdy

Resultado de la investigación: Articlerevisión exhaustiva

62 Citas (Scopus)

Resumen

Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability. Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), had higher affinity at opioid receptors than at adrenergic receptors while the vice versa was observed for corynantheidine. The observed polypharmacology of kratom alkaloids may support its utilization to treat opioid use disorder and withdrawal.

Idioma originalEnglish (US)
Páginas (desde-hasta)433-439
Número de páginas7
PublicaciónJournal of Medicinal Chemistry
Volumen63
N.º1
DOI
EstadoPublished - ene. 9 2020

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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