TY - JOUR
T1 - Investigation of tcdd half-life heterogeneity in veterans of operation ranch hand
AU - Michalek, Joel E.
AU - Tripathi, Ram C.
AU - Caudill, Samuel P.
AU - Pirkle, James L.
PY - 1992/1
Y1 - 1992/1
N2 - The half-life of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), the contaminant of Agent Orange, has been recently estimated in 36 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam, as 7.1 yr with a 90% confidence interval of 5.8-9.6 yr. We investigated the variability of TCDD half-life with percent body fat in these 36 Ranch Hand veterans who have two TCDD assay results from serum drawn in 1982 and 1987. Using a repeated measures linear model, we found a marginally significant change in half-life with percentage of body fat fp -.09) and no statistically significant change in half-life with relative changes in percentage of body fat from 1982 to 1987 (p -.60).
AB - The half-life of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), the contaminant of Agent Orange, has been recently estimated in 36 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam, as 7.1 yr with a 90% confidence interval of 5.8-9.6 yr. We investigated the variability of TCDD half-life with percent body fat in these 36 Ranch Hand veterans who have two TCDD assay results from serum drawn in 1982 and 1987. Using a repeated measures linear model, we found a marginally significant change in half-life with percentage of body fat fp -.09) and no statistically significant change in half-life with relative changes in percentage of body fat from 1982 to 1987 (p -.60).
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U2 - 10.1080/15287399209531591
DO - 10.1080/15287399209531591
M3 - Article
C2 - 1728664
AN - SCOPUS:0026573238
SN - 0098-4108
VL - 35
SP - 29
EP - 38
JO - Journal of toxicology and environmental health
JF - Journal of toxicology and environmental health
IS - 1
ER -