Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

Benjamin J. Park; Peter G. Pappas; Kathleen A. Wannemuehler; Barbara D. Alexander; Elias J. Anaissie; David R. Andes; John W. Baddley; Janice M. Brown; Lisa M. Brumble; Alison G. Freifeld; Susan Hadley; Loreen Herwaldt; James I. Ito; Carol A. Kauffman; G. Marshall Lyon; Kieren A. Marr; Vicki A. Morrison; Genovefa Papanicolaou; Thomas F. Patterson; Trish M. Perl; Mindy G. Schuster; Randall Walker; John R. Wingard; Thomas J. Walsh; Dimitrios P. Kontoyiannis

doi:10.3201/eid1710.110087

Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

Benjamin J. Park, Peter G. Pappas, Kathleen A. Wannemuehler, Barbara D. Alexander, Elias J. Anaissie, David R. Andes, John W. Baddley, Janice M. Brown, Lisa M. Brumble, Alison G. Freifeld, Susan Hadley, Loreen Herwaldt, James I. Ito, Carol A. Kauffman, G. Marshall Lyon, Kieren A. Marr, Vicki A. Morrison, Genovefa Papanicolaou, Thomas F. Patterson, Trish M. PerlMindy G. Schuster, Randall Walker, John R. Wingard, Thomas J. Walsh, Dimitrios P. Kontoyiannis

Department of Medicine

Resultado de la investigación: Article › revisión exhaustiva

197 Citas (Scopus)

Resumen

Recent reports describe increasing incidence of non- Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identifled 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.

Idioma original	English (US)
Páginas (desde-hasta)	1855-1864
Número de páginas	10
Publicación	Emerging Infectious Diseases
Volumen	17
N.º	10
DOI	https://doi.org/10.3201/eid1710.110087
Estado	Published - oct 2011

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Epidemiology

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10.3201/eid1710.110087

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Park, B. J., Pappas, P. G., Wannemuehler, K. A., Alexander, B. D., Anaissie, E. J., Andes, D. R., Baddley, J. W., Brown, J. M., Brumble, L. M., Freifeld, A. G., Hadley, S., Herwaldt, L., Ito, J. I., Kauffman, C. A., Lyon, G. M., Marr, K. A., Morrison, V. A., Papanicolaou, G., Patterson, T. F., ... Kontoyiannis, D. P. (2011). Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006. Emerging Infectious Diseases, 17(10), 1855-1864. https://doi.org/10.3201/eid1710.110087

Park, BJ, Pappas, PG, Wannemuehler, KA, Alexander, BD, Anaissie, EJ, Andes, DR, Baddley, JW, Brown, JM, Brumble, LM, Freifeld, AG, Hadley, S, Herwaldt, L, Ito, JI, Kauffman, CA, Lyon, GM, Marr, KA, Morrison, VA, Papanicolaou, G, Patterson, TF, Perl, TM, Schuster, MG, Walker, R, Wingard, JR, Walsh, TJ & Kontoyiannis, DP 2011, 'Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006', Emerging Infectious Diseases, vol. 17, n.º 10, pp. 1855-1864. https://doi.org/10.3201/eid1710.110087

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title = "Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006",

abstract = "Recent reports describe increasing incidence of non- Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identifled 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.",

author = "Park, {Benjamin J.} and Pappas, {Peter G.} and Wannemuehler, {Kathleen A.} and Alexander, {Barbara D.} and Anaissie, {Elias J.} and Andes, {David R.} and Baddley, {John W.} and Brown, {Janice M.} and Brumble, {Lisa M.} and Freifeld, {Alison G.} and Susan Hadley and Loreen Herwaldt and Ito, {James I.} and Kauffman, {Carol A.} and Lyon, {G. Marshall} and Marr, {Kieren A.} and Morrison, {Vicki A.} and Genovefa Papanicolaou and Patterson, {Thomas F.} and Perl, {Trish M.} and Schuster, {Mindy G.} and Randall Walker and Wingard, {John R.} and Walsh, {Thomas J.} and Kontoyiannis, {Dimitrios P.}",

year = "2011",

month = oct,

doi = "10.3201/eid1710.110087",

language = "English (US)",

volume = "17",

pages = "1855--1864",

journal = "Emerging Infectious Diseases",

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T1 - Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

AU - Park, Benjamin J.

AU - Pappas, Peter G.

AU - Wannemuehler, Kathleen A.

AU - Alexander, Barbara D.

AU - Anaissie, Elias J.

AU - Andes, David R.

AU - Baddley, John W.

AU - Brown, Janice M.

AU - Brumble, Lisa M.

AU - Freifeld, Alison G.

AU - Hadley, Susan

AU - Herwaldt, Loreen

AU - Ito, James I.

AU - Kauffman, Carol A.

AU - Lyon, G. Marshall

AU - Marr, Kieren A.

AU - Morrison, Vicki A.

AU - Papanicolaou, Genovefa

AU - Patterson, Thomas F.

AU - Perl, Trish M.

AU - Schuster, Mindy G.

AU - Walker, Randall

AU - Wingard, John R.

AU - Walsh, Thomas J.

AU - Kontoyiannis, Dimitrios P.

PY - 2011/10

Y1 - 2011/10

N2 - Recent reports describe increasing incidence of non- Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identifled 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.

AB - Recent reports describe increasing incidence of non- Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identifled 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.

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Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

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