@article{fde419932d694b81993d53bdc0d54d1c,
title = "Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner",
abstract = "Mouse invariant natural killer T cells (iNKT cells) provide cognate and noncognate help for lipid and protein-specific B cells, respectively. However, the long-term outcome for B cells after cognate help is provided by iNKT cells is unknown at present. Here we found that cognate iNKT cell help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal-center formation, affinity maturation and a robust primary immunoglobulin G (IgG) antibody response that was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21). However, cognate help from iNKT cells did not generate an enhanced humoral memory response. Thus, cognate iNKT cell help for lipid-specific B cells induces a unique signature that is a hybrid of classic T cell-dependent and T cell-independent type 2 B cell responses.",
author = "King, {Irah L.} and Anne Fortier and Michael Tighe and John Dibble and Watts, {Gerald F.M.} and Natacha Veerapen and Haberman, {Ann M.} and Besra, {Gurdyal S.} and Markus Mohrs and Brenner, {Michael B.} and Leadbetter, {Elizabeth A.}",
note = "Funding Information: We thank M. Nussenzweig (Rockefeller University) for B6.SJL B1-8hi mice; M. Exley (Dana Farber Cancer Institute) for C57BL/6 Vα14-transgenic mice and C57BL/6 Jα18-deficient mice; K. Rajewsky (Center for Blood Research) for B1-8f mice; M. Rincon (University of Vermont) for IL-21-deficient mice; and the US National Institutes of Health Tetramer Core for mouse CD1d-PBS57 tetramers and unloaded CD1d tetramers. Supported by the Trudeau Institute (E.A.L.), the US National Institutes of Health (AI028973-23 and AI063428-06 to M.B.B. and T32 A1049823-10 to I.L.K.), J. Bardrick (G.S.B.), the Royal Society (G.S.B.), The Wellcome Trust (084923/B/08/Z to G.S.B.) and the Medical Research Council (G.S.B.).",
year = "2012",
month = jan,
doi = "10.1038/ni.2172",
language = "English (US)",
volume = "13",
pages = "44--50",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Research",
number = "1",
}