Intestinal Metabolism in Thiamine Deficiency

G. I. Henderson, D. W. McCandless, S. Schenker

Resultado de la investigación: Articlerevisión exhaustiva

5 Citas (Scopus)

Resumen

Severe thiamine deficiency in rats was found to depress intestinal mucosal pyruvate decarboxylase and transketolase activities by 56 and 93% (p < 0.05), respectively. Whole gut transketolase activity in thiamine deficiency was also reduced by 70-80% (p < 0.05). Despite the major decline in intestinal pyruvate decarboxylase activity, ATP levels in both mucosa and whole gut of thiamine-deficient rats remained normal. By contrast, the decrease in mucosal transketo-lase activity in thiamine-deficient animals was accompanied by a 40% decline in pentose cycle activity (p < 0.05), which reverted to normal after administration of thiamine.

Idioma originalEnglish (US)
Páginas (desde-hasta)596-602
Número de páginas7
PublicaciónProceedings of the Society for Experimental Biology and Medicine
Volumen144
N.º2
DOI
EstadoPublished - nov 1973
Publicado de forma externa

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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