@article{85715a4de3e9404fbeb7d861aa9dbe41,
title = "Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia",
abstract = "Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer's type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.",
keywords = "Alzheimer's disease, dementia, inflammation, interleukin-6, sleep apnea, sleep disorders, sleep-disordered breathing",
author = "Baril, {Andr{\'e}e Ann} and Beiser, {Alexa S.} and Susan Redline and McGrath, {Emer R.} and Gottlieb, {Daniel J.} and Hugo Aparicio and Sudha Seshadri and Himali, {Jayandra J.} and Pase, {Matthew P.}",
note = "Funding Information: The authors would like to thank the staff and participants of the Framingham Heart Study and the Sleep Heart Health Study. The Framingham Heart study and Dr. Seshadri are funded by contracts from the National Health Institutes (N01-HC-25195, HHSN268201500001I, 75N92019D00031), grants from the National Institute on Aging (AG054076, AG008122). Dr. Baril is funded by the Fonds de la Recherche du Qu{\'e}bec en Sant{\'e} (#260192) and the Canadian Institutes of Health Research (#396130). Dr. Redline is partially supported by funds from the National Heart, Lung and Blood Institute (R35 135818). Dr. Pase is funded by a National Heart Foundation of Australia Future Leader Fellowship (ID 102052), the National Health and Medical Research Council (APP1158384), the Alzheimer{\textquoteright}s Association (AARG-18-591358), and the Bethlehem Griffiths Research Foundation. Dr. Pase and Dr. Himali are also supported by a grant from the National Institute on Aging (AG062531). Publisher Copyright: {\textcopyright} 2021 - IOS Press. All rights reserved.",
year = "2021",
doi = "10.3233/JAD-200545",
language = "English (US)",
volume = "79",
pages = "1451--1457",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "4",
}