TY - JOUR
T1 - Interferon Induction by Rhinoviruses and Effect of Interferon on Rhinovirus Yields in Human Cell Lines
AU - Stoker, D.
AU - Kiernat, J.
AU - Gauntt, C.
N1 - Funding Information:
This work was supported by a U.S. Public Health Service grant AI-09040 from the National Institute of Allergy and Infectious Diseases and by a grant from the Damon Runyon Memorial Fund for Cancer Research, Inc., DRG-1036. 5 1973 143 1 23 27
PY - 1973/5
Y1 - 1973/5
N2 - Rhinovirus serotypes 13, 14, and 20 did not induce detectable levels of interferon in HeLa, KB, or L-132 cells following challenge with infectious, uv-in-activated, or heat-inactivated virus preparations. HeLa cell cultures incubated with interferon prior to challenge with the three rhinovirus serotypes also failed to produce interferon. No resistance to VSV plaque formation was induced in HeLa cell cultures previously challenged with uv- or heat-inactivated lysates of the three rhinovirus serotypes. Replication of the three rhinovirus serotypes in HeLa cell cultures was inhibited by the action of interferon with an order of sensitivity being RV13 < RV14 < RV20.
AB - Rhinovirus serotypes 13, 14, and 20 did not induce detectable levels of interferon in HeLa, KB, or L-132 cells following challenge with infectious, uv-in-activated, or heat-inactivated virus preparations. HeLa cell cultures incubated with interferon prior to challenge with the three rhinovirus serotypes also failed to produce interferon. No resistance to VSV plaque formation was induced in HeLa cell cultures previously challenged with uv- or heat-inactivated lysates of the three rhinovirus serotypes. Replication of the three rhinovirus serotypes in HeLa cell cultures was inhibited by the action of interferon with an order of sensitivity being RV13 < RV14 < RV20.
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U2 - 10.3181/00379727-143-37245
DO - 10.3181/00379727-143-37245
M3 - Article
C2 - 4349971
AN - SCOPUS:0015621990
SN - 1535-3702
VL - 143
SP - 23
EP - 27
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
IS - 1
ER -