Interactions between effecters linked to serotonin receptors

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31 Citas (Scopus)

Resumen

In general, there are two types of interactions between effector signaling pathways. 'Homologous' interactions are those that occur within a receptor system to alter its own responsiveness, for example the loss of responsiveness (desensitization) that can occur upon agonist occupancy of a receptor. 'Heterologous' interactions are those that occur between different receptor systems where the responsiveness of one receptor system is regulated (positively or negatively) by activation of another receptor system (i.e., 'cross-talk'), Many, if not all receptors, couple to multiple cellular effector pathways and alterations in the responsiveness of a receptor system can be effector pathway-dependent which underscores the importance of studying each effector coupled to a receptor. Regulation of receptor system responsiveness, and consequently the efficacy of drugs, is a highly dynamic process. Perhaps by exploiting these interactions, new targets for pharmacotherapy may be uncovered which will provide for increased efficacy and specificity of drug action.

Idioma originalEnglish (US)
Páginas (desde-hasta)111-120
Número de páginas10
PublicaciónAnnals of the New York Academy of Sciences
Volumen861
DOI
EstadoPublished - 1998

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience
  • History and Philosophy of Science

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