Integrative Analysis of Circulating Metabolite Levels That Correlate With Physical Activity and Cardiorespiratory Fitness

TY - JOUR

T1 - Integrative Analysis of Circulating Metabolite Levels That Correlate With Physical Activity and Cardiorespiratory Fitness

AU - Nayor, Matthew

AU - Chernofsky, Ariel

AU - Miller, Patricia E.

AU - Spartano, Nicole L.

AU - Murthy, Venkatesh L.

AU - Malhotra, Rajeev

AU - Houstis, Nicholas E.

AU - Murabito, Joanne M.

AU - Clish, Clary B.

AU - Larson, Martin G.

AU - Vasan, Ramachandran S.

AU - Shah, Ravi V.

AU - Lewis, Gregory D.

N1 - Funding Information: The Framingham Heart Study is supported by the National Heart, Lung and Blood Institute (NHLBI) Contracts N01-HC-25195, HHSN268201500001I, and 75N92019D00031. This work was supported by National Institutes of Health (NIH) grants K23-HL138260 and R01-HL156975 (Dr Nayor), R01-HL131029 (Dr Vasan and Dr Lewis), and American Heart Association (AHA) grant 15GPSGC24800006 (Dr Lewis). Dr Nayor is supported by a Career Investment Award from the Department of Medicine, Boston University School of Medicine. Dr Malhotra was supported by the National Heart, Lung, and Blood Institute (R01HL142809), the AHA (18TPA34230025), and the Wild Family Foundation. Dr Vasan is supported in part by the Evans Medical Foundation and the Jay and Louis Coffman Endowment from the Department of Medicine, Boston University School of Medicine. Funding Information: Dr Spartano acknowledges research support from the Alzheimer’s Association and has also received funding from Novo Nordisk for an MD-initiated research grant unrelated to the current paper. Dr Murthy has stock holdings in General Electric and receives research funding from Siemens. Dr Malhotra receives research funding from Bayer and Amgen and serves as a consultant for Myokardia/Bristol Myers Squibb and Third Pole. Dr Malhotra is a co-founder of Patch, Inc. Dr Malhotra is a coinventor for a patent on pharmacological bone morphogenic protein inhibitors (along with Mass General Brigham) for which he receives royalties. Dr Malhotra receives royalties from UpToDate for scientific content authorship. Dr Murabito has served as a guest lecturer/consultant at Merck. Dr Shah is supported in part by grants from the National Institutes of Health and the American Heart Association. In the past 12 months, Dr Shah has served as a consultant for Myokardia (ongoing) and Best Doctors (ongoing), receives research funding from Amgen (concluded), had minor stock holdings in Gilead, and his spouse has current stock holdings in Pfizer. Dr Shah is a coinventor on a patent for extracellular RNA signatures of cardiac remodeling. Dr Lewis acknowledges research funding from the National Institutes of Health and the American Heart Association as well as Amgen, Cytokinetics, Applied Therapeutics, AstraZeneca, Sonivie in relation to projects and clinical trials investigating exercise capacity that are distinct from this work. He has served as a scientific advisor for Pfizer, Merck, Boehringer-Ingelheim, Novartis, American Regent, Relypsa, Cyclerion, Cytokinetics, and Amgen and receives royalties from UpToDate for scientific content authorship related to exercise physiology. The other authors report no conflicts.

PY - 2022/6/1

Y1 - 2022/6/1

KW - accelerometry

KW - cardiorespiratory fitness

KW - exercise

KW - exercise test

KW - metabolomics

KW - risk

UR - http://www.scopus.com/inward/record.url?scp=85132454176&partnerID=8YFLogxK

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U2 - 10.1161/CIRCGEN.121.003592

DO - 10.1161/CIRCGEN.121.003592

M3 - Article

C2 - 35536222

AN - SCOPUS:85132454176

SN - 1942-325X

VL - 15

SP - E003592

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

IS - 3

ER -